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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P9103-41K.100 | 100 µl | - | - |
3 - 19 business days* |
909.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Kinase C eta (PKCeta) is an 80kD member of the novel group (nPKCs: sensitive to... more
Product information "Anti-phospho-Protein Kinase C, eta (Thr655) (PKCeta)"
Protein Kinase C eta (PKCeta) is an 80kD member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, transcriptional regulation and tumor promotion. PKC eta has been shown to be involved in the cell cycle as ectopic expression results in elevated expression of cyclins D and E and its association with the cyclinE/cdk2/p21 complex inhibits cdk2 kinase activity, leading to G1 arrest. PKC eta is also involved in mediating FGF and PDGF ability to stimulate IL-6 production and PKCm modulation of ERK and JNK signaling pathways. The activation loop threonine (threonine 512 in PKC eta) of novel PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1) and is necessary for the autophosphorylation of threonine 655 in the carboxy-terminus of PKC eta, a step that may play a role in mediating PKC eta signaling events. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cells treated with PMA, a phorbol ester, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-phospho-PKCL, Anti-phospho-PRKCH, Anti-phospho-PKC-L, Anti-phospho-nPKC-eta, EC=2.7.11.13, Anti-phospho-Protein kinase C eta type |
Supplier: | United States Biological |
Supplier-Nr: | P9103-41K |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic phosphopeptide derived from a region of human PKC eta that contains threonine 655. Species Sequence Homology: mouse and rat, 100% |
Format: | Affinity Purified |
Database Information
KEGG ID : | K18051 | Matching products |
UniProt ID : | P24723 | Matching products |
Gene ID | GeneID 5583 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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