Anti-PKC-eta

Anti-PKC-eta
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-236A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-236A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-236A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent... more
Product information "Anti-PKC-eta"
Protein function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1- dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. [The UniProt Consortium]
Keywords: Anti-PKCL, Anti-PKC-L, Anti-PRKCH, Anti-nPKC-eta, EC=2.7.11.13, Anti-Protein kinase C eta type
Supplier: Bethyl Laboratories
Supplier-Nr: A304-236A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A304-236A-T maps to a region between residue 633 to 683 of human Protein Kinase C, Eta using the numbering given in entry NP_006246.2 (GeneID 5583).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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