Anti-phospho-DAXX (Ser213) (Death Domain-associated Protein 6, Daxx, hDaxx, Fas Death Domain-associa

Anti-phospho-DAXX (Ser213) (Death Domain-associated Protein 6, Daxx, hDaxx, Fas Death Domain-associa
Item number Size Datasheet Manual SDS Delivery time Quantity Price
D1150-05A.200 200 µl - -

3 - 19 business days*

728.00€
 
DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to... more
Product information "Anti-phospho-DAXX (Ser213) (Death Domain-associated Protein 6, Daxx, hDaxx, Fas Death Domain-associa"
DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-phospho-ETS1-associated protein 1, Anti-phospho-Death domain-associated protein 6, Anti-phospho-Fas death domain-associated protein
Supplier: United States Biological
Supplier-Nr: D1150-05A

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-DAXX (Ser213) (Death Domain-associated Protein 6, Daxx, hDaxx, Fas Death Domain-associa"
Write a review
or to review a product.
Viewed