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Anti-phospho-c-Kit (Tyr362)

Anti-phospho-c-Kit (Tyr362)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F48716-0.08ML 80 µl - -

3 - 10 business days

207.00€
NSJ-F48716-0.4ML 400 µl - -

3 - 10 business days

503.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the human homolog of the... more
Product information "Anti-phospho-c-Kit (Tyr362)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. [The UniProt Consortium]
Keywords: Anti-phospho-KIT, Anti-phospho-PBT, Anti-phospho-SCFR, Anti-phospho-CD117, Anti-phospho-p145 c-kit, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-Kit, Anti-phospho-Piebald trait protein, Anti-phospho-Tyrosine-protein kinase Kit, Phospho-c-Kit Antibody (pY362
Supplier: NSJ Bioreagents
Supplier-Nr: F48716-0.08ML

Properties

Application: Dot Blot, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: This phospho-c-Kit antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY362 of human c-Kit.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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