Anti-phospho-BLM (Ser527)

Anti-BLM pS527 was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with human based on 100% sequence homology. Cross-reactivity with BLM pS527 from other sources has not been determined. BLM pS527 product is a member of the RecQ helicase protein family. The protein contains 1417 amino acids. including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. BLS protein is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. The Bloom's syndrome gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes. Anti-BLM pS527 antibody is ideal for researchers interested in Epigenetics and Nuclear Signaling or DNA Damage & Repair research.