Anti-phospho-ATM Protein Kinase (Ser1981)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-601-400S 25 µl - -

1 - 9 business days

132.00€
600-601-400 100 µg - -

1 - 9 business days

493.00€
 
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... more
Product information "Anti-phospho-ATM Protein Kinase (Ser1981)"
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. [The UniProt Consortium]
Keywords: Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia telangiectasia mutated
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-601-400S

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Sheep
Reactivity: Human
Immunogen: synthetic phospho-peptide corresponding to a region near serine 1981 of human ATM

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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