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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32242-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GluR1 is a subunit of the AMPA ionotropic glutamate receptor, which is responsible for fast... more
Product information "Anti-GluR1 (Phospho-Ser845) Rabbit Monoclonal Antibody (Clone RM296)"
GluR1 is a subunit of the AMPA ionotropic glutamate receptor, which is responsible for fast excitatory synaptic transmission in the CNS. AMPA receptors are composed of four subunits, GluR1, GluR2, GluR3, and GluR4, which combine into heterotetramers to form a cation-permeable pore in the plasma membrane. Each subunit has two isoforms with the primary isoform designated as flip and a second isoform generated through alternative splicing designated as flop. The GluR1 flip and flop isoforms do not affect desensitization or channel opening and closing kinetics. GluR1 can be phosphorylated by PKA at serine 845 (Ser845), which increases the peak open probability of the ion channel, and dephosphorylation is required for AMPA receptor endocytosis. GluR1 (phospho-Ser845) levels increase in the ventromedial prefrontal cortex (vmPFC) and nucleus accumbens (NAc) following cocaine-cue extinction. Levels of GluR1 (phospho-Ser845) are reduced following NMDA receptor activation in rat hippocampal slices and by amyloid-beta (Abeta) oligomers in primary mouse neurons. Cayman's GluR1 (Phospho-Ser845) Rabbit Monoclonal Antibody (Clone RM296) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: AMPA-selective Glutamate Receptor 1, GluA1, GluR-1, GluR-A. Immunogen: Peptide corresponding to human GluR1 (phospho-Ser845). Clone Designation: RM296. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) GluR1 (phospho-Ser845), (-) GluR1 without phosphorylation at Ser845.
Keywords: | AMPA-selective Glutamate Receptor 1, GluA1, GluR-1, GluR-A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32242 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM296 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide corresponding to human GluR1 (phospho-Ser845) |
Format: | Purified |
Database Information
KEGG ID : | K05197 | Matching products |
UniProt ID : | P42261 | Matching products |
Gene ID | GeneID 2890 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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