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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
REV-31-1179-00-R100 | 100 µl | - | - |
3 - 9 business days* |
483.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant Antibody. This antibody reacts to human Glutamate Receptor 1, AMPA Receptor (GluR1)... more
Product information "Anti-Phospho-AMPA Receptor (Ser845) (human), Rabbit Monoclonal (RM296)"
Recombinant Antibody. This antibody reacts to human Glutamate Receptor 1, AMPA Receptor (GluR1) only when phosphorylated at Ser845. There is no cross-reactivity to GluR1 that is not phosphorylated at Ser845. This antibody may also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. AMPA receptors (AMPARs) are heterotetrameric complexes composed of subunits GluR1-4, each of them conferring specific properties on the active receptor, including trafficking motifs, which is related to synaptic plasticity. These glutamate receptors are responsible for the fast, immediate postsynaptic response to glutamate release. Therefore, the receptor-channel complex, predominantly permeable for sodium and potassium ions, activates fast and shows rapid desensitization. AMPA receptors are abundant and widely distributed in the central nervous system. GluR1 (Glutamate Receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Phosphorylation of GluR1 is critical for long-term potentiation (LTP) and long-term depression (LTD) expression and the retention of memories.
Keywords: | Glutamate Receptor 1, GluR 1, GluA1, GluR-A, GluR-K1 |
Supplier: | RevMAb Biosciences |
Supplier-Nr: | 31-1179-00 |
Properties
Application: | WB, IHC |
Antibody Type: | Monoclonal |
Clone: | RM296 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K05197 | Matching products |
UniProt ID : | P42261 | Matching products |
Gene ID | GeneID 2890 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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