Protein function: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. [The UniProt Consortium]
Anti-YB-1, Anti-DBPB, Anti-YBX1, Anti-EFI-A, Anti-NSEP1, Anti-CBF-A, Anti-DNA-binding protein B, Anti-Y-box-binding protein 1, Anti-Y-box transcription factor, Anti-Enhancer factor I subunit A, Anti-Nuclease-sensitive element-binding protein 1
WB, IP, IHC
Human, Mouse (Expected: Rat, X. Laevis, Chicken, Bovine, Rabbit)
synthetic peptide. The epitope recognized by A303-230A-T maps to a region between residue 224 and 274 of human Y Box Binding Protein 1 using the numbering given in entry NP_004550. (GeneID 4904).