Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
V2110-16N.100 | 100 µg | - | - |
3 - 19 business days* |
871.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Embryonic vascular system undergoes a series of complex, highly regulated series of events... more
Product information "Anti-VEGFR1 (Vascular Endothelial Growth Factor Receptor 1, VEGFR-1, Fms-like Tyrosine Kinase 1, FLT"
Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor. VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR-1 (flt-1/flk-2), VEGFR-2 (flk-1/KDR), and VEGFR-3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. FLT-1 (fms-like tyrosine kinase or VEGF-R1, human 1338 aa, rat 1336aa, and mouse 1333), a putative receptor protein tyrosine kinase, is a receptor for VEGF and PLGF. Mature full length protein is aa27-1338 (EC domain 27-758 aa). It is type 1 membrane protein and also exist as soluble protein. FLT-1 region aa657-687 (DQEAPYLLRNLSDHTVAISSSTTLD, CHANGVGEHCNK) is changed to KAVFSRISKFKSTRNDCTTQSNVKH in soluble FLT- 1. Additional isoforms seem to exist as well. Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Soluble Isoform (sFlt1) is strongly expressed in placenta., Applications:, Suitable for use in Western Blot, ELISA and Flow Cytometry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml. Human recombinant baculovirus expressed VEGFR1 at ~166-200kD., ELISA: 1:10,000-1:100,000, Flow Cytometry: 25ug/ml.10-20ul of diluted antibody labels 1-2x10e5 cells in a total volume of 200-250ul., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | V2110-16N |
Properties
Application: | ELISA, FC, WB |
Antibody Type: | Monoclonal |
Clone: | 11C164 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human FLT1, EC-domain (27-758 aa). |
Format: | Affinity Purified |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed