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Anti-VEGFR-2/KDR (human), clone EIC

Anti-VEGFR-2/KDR (human), clone EIC
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-20T-0108-C100 100 µg -

3 - 9 business days

413.00€
 
The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of... more
Product information "Anti-VEGFR-2/KDR (human), clone EIC"
The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types. Lyophilized. Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not been previously described. A splice variant of the gene encoding vascular endothelial growth factor receptor-2 (VEGFR-2) that encodes a secreted form of the protein, designated endogenous soluble VEGFR-2 (esVEGFR-2/KDR) has been described. The endogenous soluble esKDR inhibits developmental and reparative lymphangiogenesis by blocking VEGF-C function. Tissue-specific loss of esKDR in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of esKDR inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring esKDR thus acts as a molecular uncoupler of blood and lymphatic vessels, modulation of esKDR might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema.
Keywords: Anti-KDR, Anti-FLK1, Anti-CD309, Anti-FLK-1, Anti-VEGFR2, EC=2.7.10.1, Anti-VEGFR-2, Anti-Fetal liver kinase 1, Anti-Kinase insert domain receptor, Anti-Protein-tyrosine kinase receptor flk-1, Anti-Vascular endothelial growth factor receptor 2
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-20T-0108-C100

Properties

Application: ELISA, FC, IHC, WB
Antibody Type: Monoclonal
Clone: EIC
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human soluble extracellular VEGFR-2.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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