335 products were found matching "K05098"!

transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells.

Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of...

The kinase insert domain receptor (KDR), also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a type IV receptor tyrosine kinase that plays a crucial role in various biological processes, including embryonic vasculature development, angiogenesis regulation, cell survival, migration, macrophage...

VEGF-R2 belongs to a family of proteins called receptor tyrosine kinases. The receptor has three main parts: one part extends out of the cell and binds to VEGF, another spans the cell's membrane, while the third part is found inside the cell. The current model of VEGF-R2 activation is that VEGF binds to individual...

A VEGFR2 inhibitor (IC50 = 23 nM), selective for VEGFR2 over 22 other kinases (IC50s = 400->10,000 nM), inhibits VEGF-induced proliferation in HUVECs (IC50 = 25 nM), decreases tumor volume in an L2987 lung adenocarcinoma mouse xenograft model at 90 or 180 mg/kg per day

A VEGFR1, VEGFR2, and EGFR inhibitor (IC50s = 0.7, 0.03, and 0.4 µM, respectively), selective for these kinases over PDGFRbeta, FGFR1, and HER2 (IC50s = 3.4, >100, and >100 µM, respectively) and MEK, Cdk2, IGF-1R, Akt, and Tie2 (IC50s = >10, >10, >20, >20, and >100 µM, respectively), selectively inhibits VEGF- or...

c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.

Tie2/VEGFR2 kinase-IN-2 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGFR2 (IC50s = 13. and 7. nM, respectively). It is selective for Tie2 and VEGFR2 over Akt3, cyclin-dependent kinase 2 (Cdk2), EGFR, and glycogen synthase kinase 3 (GSK3, IC50s = >10,000, >10,000, 10,000, and 2,187 nM,...

VEGFR2, also known as kinase insert domain receptor (KDR), is a receptor tyrosine kinase that has roles in vascular permeability, cell proliferation and survival, and angiogenesis. It is composed of an N-terminal extracellular ligand-binding domain, which contains seven immunoglobulin-like (Ig-like) domains, a...

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...

Vascular endothelial growth factor receptor 2 (VEGFR2), also called Kinase insert Domain receptor (KDR), is a tyrosine kinase (TK) receptor for VEGFs that plays a central role in tumor angiogenesis, therefore the inhibition of VEGFR2 is a promising therapeutic strategy for inhibiting angiogenesis and tumor growth....

XL184 is an inhibitor of VEGFR2 (IC50 = 0.035 nM). It is selective for VEGFR2 over Ron, EGFR, IGF-1R, and EphA4/B4, but also inhibits c-Met, RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 1.3, 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). XL184 (4.6 nM) inhibits VEGF-induced tubule formation in human microvascular...