356 products were found matching "K05098"!

VEGFR2 kinase inhibitor IV is an inhibitor of VEGFR2 (IC50 = 19 nM). It is greater than 100-fold selective for VEGFR2 over FGFR1 and Src but only 1.8-, 10-, and 10-fold selective over PDGFRbeta, FLT1, and FLT2, respectively. VEGFR2 kinase inhibitor IV inhibits mitogenesis in human umbilical vein endothelial cells...

Description: VEGFR2/KDR Protein, Mouse, Recombinant (aa 192-761, hFc) is expressed in HEK293 Cells. The accession number is P35918.

Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of...

c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.

A VEGFR1, VEGFR2, and EGFR inhibitor (IC50s = 0.7, 0.03, and 0.4 µM, respectively), selective for these kinases over PDGFRbeta, FGFR1, and HER2 (IC50s = 3.4, >100, and >100 µM, respectively) and MEK, Cdk2, IGF-1R, Akt, and Tie2 (IC50s = >10, >10, >20, >20, and >100 µM, respectively), selectively inhibits VEGF- or...

A VEGFR2 inhibitor (IC50 = 23 nM), selective for VEGFR2 over 22 other kinases (IC50s = 400->10,000 nM), inhibits VEGF-induced proliferation in HUVECs (IC50 = 25 nM), decreases tumor volume in an L2987 lung adenocarcinoma mouse xenograft model at 90 or 180 mg/kg per day

Vascular endothelial growth factor receptor 2 (VEGFR2), also called Kinase insert Domain receptor (KDR), is a tyrosine kinase (TK) receptor for VEGFs that plays a central role in tumor angiogenesis, therefore the inhibition of VEGFR2 is a promising therapeutic strategy for inhibiting angiogenesis and tumor growth....

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...

XL184 is an inhibitor of VEGFR2 (IC50 = 0.035 nM). It is selective for VEGFR2 over Ron, EGFR, IGF-1R, and EphA4/B4, but also inhibits c-Met, RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 1.3, 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). XL184 (4.6 nM) inhibits VEGF-induced tubule formation in human microvascular...

Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2, IC50 = 1 nM). It is less effective against c-kit (IC50 = 429 nM), Ret (IC50 = 13 nM), and c-src (IC50 = 53 nM) and does not inhibit EGFR, Her-2, or FGFR1 (IC50s = >10 µM). Apatinib...

SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRbeta (IC50s = 0.02, 0.03, and 0.51 µM, respectively). It is much less effective against other receptor tyrosine kinases. SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.Formal Name:...

Tie2/VEGFR2 kinase-IN-2 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGFR2 (IC50s = 13. and 7. nM, respectively). It is selective for Tie2 and VEGFR2 over Akt3, cyclin-dependent kinase 2 (Cdk2), EGFR, and glycogen synthase kinase 3 (GSK3, IC50s = >10,000, >10,000, 10,000, and 2,187 nM,...