Anti-USP8

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-929A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-929A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-929A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore... more
Product information "Anti-USP8"
Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. [The UniProt Consortium]
Keywords: Anti-USP8, Anti-hUBPy, Anti-KIAA0055, Anti-Ubiquitin thioesterase 8, Anti-Ubiquitin isopeptidase Y, Anti-Deubiquitinating enzyme 8, Anti-Ubiquitin carboxyl-terminal hydrolase 8, Anti-Ubiquitin-specific-processing protease 8
Supplier: Bethyl Laboratories
Supplier-Nr: A302-929A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-929A-T maps to a region between residue 400 and 450 of human Ubiquitin Specific Peptidase 8 using the numbering given in entry NP_005145.3 (GeneID 9101).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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