29 products were found matching "K11839"!

DUB-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 0.56 µM). It is selective for USP8 over USP7 (IC50 = >100 µM). DUB-IN-3 is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro) when Z-LRGG-AMC is used as a substrate (IC50 = 12.5 µM) but...

USP8-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 2.6 µM). It is selective for USP8 over USP7 (IC50 = >20 µM). USP8-IN-1 inhibits colony formation by H1975 non-small cell lung cancer (NSCLC) cells (IC50 = 30.8 µM).Formal Name:...

USP8-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 6 µM).Formal Name: N-(5-chloro-2-methoxyphenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea. CAS Number: 2477651-11-7. Synonyms: Ubiquitin-specific Protease 8-IN-2, Ubiquitin-specific Protease 8 Inhibitor 2, USP Inhibitor 2....

USP8-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 4 µM). It inhibits the growth of H1975 non-small cell lung cancer (NSCLC) and GH3 rat pituitary cells (GI50s = 6.01 and 37.03 µM).Formal Name: N-(4-nitrophenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea. CAS Number:...

DUB-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 0.85 µM). It is selective for USP8 over USP7 (IC50 = >100 µM). It inhibits the proliferation of LN-229, U87MG, and T98G glioblastoma cells when used at concentrations ranging from 200 to 800 nM. DUB-IN-1 (500 and 800 nM) reduces the migration...

Description: Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively). Target: Apoptosis. Smiles:...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Human USP8 (Ubiquitin-Specific Protease 8) or UBPY, GenBank Accession No. NM_005154, amino-acids 2-1118(end) with an N-terminal FLAG-tag, MW=128 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

DUBs-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 280 nM). It is selective for USP8 over USP7 (IC50 = >100 µM). DUBs-IN-2 increases the level of programmed cell death protein ligand 1 (PD-L1) in H460 cells when used at a concentration of 2 µM and PC-9 cells at 2 and 4 µM. Intraperitoneal...