Anti-USP5

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG59512.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference... more

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Product information "Anti-USP5"

Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [The UniProt Consortium]

Keywords:	Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5, Anti-Ubiquitin carboxyl-terminal hydrolase 5, Anti-Ubiquitin-specific-processing protease 5
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG59512

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat)
Immunogen:	Recombinant fusion protein corresponding to aa. 1-280 of Human USP5 (NP_003472.2)
MW:	95 kD
Format:	Affinity Purified