Anti-USP5/IsoT

Anti-USP5/IsoT
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-543A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-543A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference... more
Product information "Anti-USP5/IsoT"
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [The UniProt Consortium]
Keywords: Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5, Anti-Ubiquitin carboxyl-terminal hydrolase 5, Anti-Ubiquitin-specific-processing protease 5
Supplier: Bethyl Laboratories
Supplier-Nr: A301-543A-T

Properties

Application: IP, IHC
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A301-543A-T maps to a region between residue 375 and 425 of human ubiquitin specific peptidase 5 (isopeptidase T) using the numbering given in entry CAA62690.1 (GeneID 8078).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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