Anti-UCH-L3

Anti-UCH-L3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-947A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A302-947A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin... more
Product information "Anti-UCH-L3"
Protein function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. [The UniProt Consortium]
Keywords: Anti-UCHL3, Anti-UCH-L3, EC=3.4.19.12, Anti-Ubiquitin thioesterase L3, Anti-Ubiquitin carboxyl-terminal hydrolase isozyme L3
Supplier: Bethyl Laboratories
Supplier-Nr: A302-947A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, bovine, pig)
Immunogen: synthetic peptide. The epitope recognized by A302-947A-T maps to a region between residue 1 and 50 of human Ubiquitin Carboxyl-Terminal Esterase L3 using the numbering given in entry NP_005993.1 (GeneID 7347).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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