Anti-Tyrosinase, clone rOCA1/812

Anti-Tyrosinase, clone rOCA1/812
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3658IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-Tyrosinase, clone rOCA1/812"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas. Protein function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6- dihydroxyindole) to indole-5,6 quinone. [The UniProt Consortium]
Keywords: Anti-TYR, Anti-LB24-AB, Anti-SK29-AB, Anti-Tyrosinase, EC=1.14.18.1, Anti-Monophenol monooxygenase, Anti-Tumor rejection antigen AB, Tyrosinase Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3658IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: rOCA1/812
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant protein was used as the immunogen for this recombinant Tyrosinase antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Tyrosinase, clone rOCA1/812"
Write a review
or to review a product.
Viewed