Anti-Tyrosinase, clone OCA1/812

Anti-Tyrosinase, clone OCA1/812
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2914SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a cluster of proteins between... more
Product information "Anti-Tyrosinase, clone OCA1/812"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas. Protein function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. [The UniProt Consortium]
Keywords: Anti-TYR, Anti-SK29-AB, Anti-LB24-AB, Anti-Tyrosinase, EC=1.14.18.1, Anti-Monophenol monooxygenase, Anti-Tumor rejection antigen AB, Tyrosinase Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2914SAF-100UG

Properties

Application: ELISA, FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: OCA1/812
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human TYR protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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