Anti-Tuberin

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F49604-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F49604-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in TSC2 lead to tuberous sclerosis complex.... more
Product information "Anti-Tuberin"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Protein function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. [The UniProt Consortium]
Keywords: Anti-TSC2, Anti-TSC4, Anti-Tuberin, Anti-Tuberous sclerosis 2 protein, Tuberin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F49604

Properties

Application: WB, IHC, IF, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 1776-1805 from the human protein was used as the immunogen for this Tuberin antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Tuberin"
Write a review
or to review a product.
Viewed