Anti-TSEN54

Anti-TSEN54
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ELK-ES5589.50 50 µl - -

10 - 14 business days*

169.00€
ELK-ES5589.100 100 µl - -

10 - 14 business days*

283.00€
 
This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the... more
Product information "Anti-TSEN54"
This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.[provided by RefSeq, Oct 2009], Protein function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Nucleus . Nucleus, nucleolus . May be transiently localized in the nucleolus. .
Keywords: Anti-SEN54, Anti-TSEN54, Anti-HsSEN54, Anti-SEN54 homolog, Anti-tRNA-intron endonuclease Sen54, Anti-tRNA-splicing endonuclease subunit Sen54, TSEN54 rabbit pAb
Supplier: ELK Biotechnology
Supplier-Nr: ES5589

Properties

Application: WB, IHC, IF, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat, mouse,
Immunogen: The antiserum was produced against synthesized peptide derived from human TSEN54. AA range:261-310
MW: 60 kD
Format: Antiserum

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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