Anti-TRIP12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-FQ1	100 µg		-	-	6 - 10 business days*		684.00€

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Anti-TRIP12 antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-TRIP12"

Anti-TRIP12 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist. Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). [The UniProt Consortium]

Keywords:	Anti-TRIM33, Anti-KIAA1113, Anti-TIF1-gamma, EC=6.3.2.-, Anti-Protein Rfg7, Anti-Ectodermin homolog, Anti-RET-fused gene 7 protein, Anti-E3 ubiquitin-protein ligase TRIM33, Anti-Tripartite motif-containing protein 33, Anti-Transcription intermediary facto
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-FQ1

Properties

Application:	ELISA, IHC, IFM, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	18 amino acid peptide near the C-terminus of human TRIP12.
Format:	Purified