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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R32355 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tripartite motif-containing 33, also known... more
Product information "Anti-TIF1 gamma / TRIM33"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tripartite motif-containing 33, also known as transcriptional intermediary factor 1 gamma (TIF1-gamma), is a human gene. The TRIM33 gene is mapped to chromosome 1p13 by FISH. The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). [The UniProt Consortium]
Keywords: | Anti-TRIM33, Anti-KIAA1113, Anti-TIF1-gamma, EC=2.3.2.27, Anti-Protein Rfg7, Anti-Ectodermin homolog, Anti-RET-fused gene 7 protein, Anti-E3 ubiquitin-protein ligase TRIM33, Anti-Tripartite motif-containing protein 33, TIF1 gamma Antibody / TRIM33 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R32355 |
Properties
Application: | WB, IHC (paraffin), FC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | amino acids 1001-1127 of human TIF1 gamma |
Format: | Purified |
Database Information
KEGG ID : | K08883 | Matching products |
UniProt ID : | Q9UPN9 | Matching products |
Gene ID | GeneID 51592 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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