Anti-Topoisomerase II alpha / TOP2A, clone FB-20

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5364 100 µl - -

3 - 10 business days*

Antibody in PBS with 0.02% sodium azide and 50% glycerol. The TOP2A gene encodes a DNA... more
Product information "Anti-Topoisomerase II alpha / TOP2A, clone FB-20"
Antibody in PBS with 0.02% sodium azide and 50% glycerol. The TOP2A gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [RefSeq] Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. [The UniProt Consortium]
Keywords: Anti-TOP2, Anti-TOP2A, EC=, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme, Topoisomerase II alpha Antibody / TOP2A
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5364


Application: IHC (paraffin), WB
Antibody Type: Monoclonal
Clone: FB-20
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide specific to human Topoisomerase II alpha / TOP2A
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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