277 products were found matching "K03164"!

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...

A racemic mixture of dexrazoxane and levrazoxane, inhibits TOP2A and TOP2B only weakly (IC50s = 301 and 505 µM, respectively), slows tumor growth, normalizes vasculature, and prevents metastases in murine Lewis lung carcinoma models at 30 mg/kg. SMILES: O=C1NC(CN(CC(C)N2CC(NC(C2)=O)=O)C1)=O. InChi Code:...

Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...

Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....

An inhibitor of topoisomerase II (IC50 = 20 µM) and xanthine oxidoreductase (IC50 = 51 µM), selective for topoisomerase II over topoisomerase I (IC50 = ~200 µM), increases lifespan in a variety of murine cancer models, including B16 melanoma, L1210 leukemia, P388 leukemia, and M5076 sarcoma models. Formulation: A...

Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a...

Daunorubicin is an antitumor antibiotic. At 0.2-1µM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells,...

Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1...

Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. [The UniProt Consortium]

Mycotoxin, Antifungal, Phytotoxic, Shown to possess DNA strand-breaking activity, Inhibits the activity of topoisomerase IIalpha (Topo IIalpha) in mammalian cells. Isolated from Alternaria sp.

Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin (Cay-15007) that undergoes beta-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin. Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID50s = 9 µM). When used either...

Pirarubicin is an anthracycline that has anticancer activity. It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively). It inhibits the growth of human Huh7 and...