277 products were found matching "K03164"!

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...

Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...

Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...

Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...

Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. DNA topoisomerase II alpha (TOP2A) is a nuclear enzyme that regulates DNA topology during replication, transcription, and chromosome segregation. The protein belongs to the type II DNA topoisomerase family and functions by creating transient double strand breaks...

A racemic mixture of dexrazoxane and levrazoxane, inhibits TOP2A and TOP2B only weakly (IC50s = 301 and 505 µM, respectively), slows tumor growth, normalizes vasculature, and prevents metastases in murine Lewis lung carcinoma models at 30 mg/kg. SMILES: O=C1NC(CN(CC(C)N2CC(NC(C2)=O)=O)C1)=O. InChi Code:...

Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....

Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a...

Daunorubicin is an antitumor antibiotic. At 0.2-1µM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells,...

Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1...

Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. [The UniProt Consortium]