Anti-Toll-Like Receptor 1

Anti-Toll-Like Receptor 1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13582-1 1 each -

6 - 10 business days*

432.00€
 
The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins... more
Product information "Anti-Toll-Like Receptor 1"
The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.Synonyms: TLR1. Immunogen: synthetic peptide from human TLR1 amino acids 400-450. Formulation: (Request formulation change), 0.1 mg of protein G-purified in 0.2 ml PBS containing 0.05% BSA and 0.05% sodium azide. Host: Rabbit. Applications: WB and FC (intracellular and cell surface). Origin: Animal/Rabbit.
Keywords: TLR1
Supplier: Cayman Chemical
Supplier-Nr: 13582

Properties

Application: WB, FC (intracellular, Cell surface)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide from human TLR1 amino acids 400-450
Format: Purified

Database Information

KEGG ID : K05398 | Matching products
UniProt ID : Q15399 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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