Anti-TLR4 (Toll-Like Receptor 4), clone TLR4/230

Anti-TLR4 (Toll-Like Receptor 4), clone TLR4/230
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2897SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with human Toll-like... more
Product information "Anti-TLR4 (Toll-Like Receptor 4), clone TLR4/230"
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [The UniProt Consortium]
Keywords: Anti-TLR4, Anti-hToll, Anti-CD284, Anti-Toll-like receptor 4, TLR4 Antibody (Toll-Like Receptor 4)
Supplier: NSJ Bioreagents
Supplier-Nr: V2897SAF-100UG

Properties

Application: FA (activity), FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: TLR4/230
Conjugate: No
Host: Mouse
Reactivity: Human, Monkey, Swine, Dog, Rat, Guinea Swine
Immunogen: Recombinant human TLR4 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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