167 products were found matching "K10160"!

Kdo2-Lipid A is the active component of LPS. It selectively induces Il-6 expression in wild-type RAW 264.7 macrophages, but not Tlr4-/- RAW 264.7 macrophages, when used at a concentration of 1 µg/ml. Kdo2-Lipid A (100 ng/ml) increases the levels of prostaglandin D2 (PGD2, Cay-12010), PGE2 (Cay-14010), and Tnf-alpha...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TLR4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TLR4. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TLR4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TLR4. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TLR4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TLR4. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Cattle TLR4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Cattle TLR4. Next,...

Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene.TLR 4 has also been designated as CD284. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Protein function: Transmembrane receptor that functions as a pattern recognition receptor...

NCI 126224 is a toll-like receptor 4 (TLR4) antagonist. NCI 126224 selectively inhibits nitric oxide (NO) production induced by the TLR4 agonist LPS (IC50 = 0.31 µM) over the TLR7/8 agonist R-848 (Cay-14806), TLR1/2 agonist Pam3CSK4 (Cay-24126), and TLR3 agonist poly(I:C) in RAW 264.7 macrophages but also inhibits...

TAK-242 is an antagonist of toll-like receptor 4 (TLR4) with an IC50 value of 0.68 µM in a secreted alkaline phosphatase (SEAP) assay. It selectively binds to TLR4 over TLR1-3 and TLR5-10 when used at a concentration of 100 nM. TAK-242 (1 µM) prevents the interaction of TLR4 with its adaptor proteins TIRAP or TRAM...

Defined substructure of the Re mutant of lipopolysaccharide (LPS), Endotoxin activity equal to Re LPS, Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4), Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA, Facilitates...

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated...

Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.1-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly...