Anti-TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein)

Anti-TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T5500-02.100 100 µg - -

3 - 19 business days*

644.00€
 
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products... more
Product information "Anti-TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein)"
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling. Applications: Suitable for use in Western Blot. and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml , Immunohistochemistry: 2ug/ml, Optimal dilution determined by the researcher. Recommended Secondary Reagents: Sheep anti rabbit IgG: HRP, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Adaptor protein Wyatt, Anti-MyD88 adapter-like protein, Anti-TIR domain-containing adapter protein, Anti-Toll/interleukin-1 receptor domain-containing adapter protein
Supplier: United States Biological
Supplier-Nr: T5500-02

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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