Anti-Thymidylate Synthase (TYMS, TS, TSase, TMS, TYMS Protein, Tyms Thymidylate Synthetase, dTMP Syn

Anti-Thymidylate Synthase (TYMS, TS, TSase, TMS, TYMS Protein, Tyms Thymidylate Synthetase, dTMP Syn
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T5155-10J.100 100 µl - -

3 - 19 business days*

675.00€
 
The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is an... more
Product information "Anti-Thymidylate Synthase (TYMS, TS, TSase, TMS, TYMS Protein, Tyms Thymidylate Synthetase, dTMP Syn"
The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is an essential step in the formation of thymine nucleotides (1,2, reviewed in 3). This process is catalyzed by thymidylate synthase (TS or TYMS), a homodimer composed of two 30kD subunits. TS is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells (1). Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU) (1-5). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck. Studies have shown that patients with metastases expressing lower levels of TS have a higher response rate to treatment with 5-FU than patients with tumors that have increased levels of TS (5). TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers (6-10). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% w/v nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=2.1.1.45, Anti-Thymidylate synthase
Supplier: United States Biological
Supplier-Nr: T5155-10J

Properties

Application: WB
Antibody Type: Monoclonal
Clone: TS106(TS106)
Conjugate: No
Host: Mouse
Species reactivity: human, monkey, mouse, rat
Immunogen: Full-length recombinant human Thymidylate Synthase.
Format: Ascites

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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