Anti-THOC1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-838A-T	10 µl (10 µg)		-		2 - 8 business days*		165.00€
A302-838A	100 µl (100 µg)		-		2 - 8 business days*		586.00€

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Protein function: Required for efficient export of polyadenylated RNA. Acts as component of the... more

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Product information "Anti-THOC1"

Protein function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. [The UniProt Consortium]

Keywords:	Anti-HPR1, Anti-Tho1, Anti-THOC1, Anti-p84N5, Anti-hTREX84, Anti-THO complex subunit 1, Anti-Nuclear matrix protein p84
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-838A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: dog, horse, rabbit, guinea pig_10141, panda, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, naked mole rat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-838A-T maps to a region between residue 550 and 600 of human THO Complex 1 using the numbering given in entry NP_005122.2 (GeneID 9984).
Format:	Antigen Affinity Purified