Anti-TGFB1 / Transforming growth factor beta-1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The TGFB1 antibody targets Transforming growth factor beta-1, a multifunctional cytokine encoded by the TGFB1 gene that regulates cell growth, differentiation, immune response, and extracellular matrix production. As a member of the TGF-beta superfamily, this secreted protein plays pivotal roles in development, tissue repair, and immune regulation. Transforming growth factor beta-1 is synthesized as a latent precursor that undergoes proteolytic activation to yield the mature cytokine. The TGFB1 antibody provides researchers with a reliable reagent to study this crucial signaling molecule and its diverse biological effects.Transforming growth factor beta-1 binds to type I and type II TGF-beta receptors, initiating phosphorylation of SMAD transcription factors that regulate gene expression. This signaling pathway influences processes such as epithelial-to-mesenchymal transition (EMT), fibrosis, angiogenesis, and immune tolerance. The TGFB1 antibody enables quantification of protein levels and distribution in tissues, helping elucidate how this cytokine coordinates cellular communication during development and wound healing.Dysregulated TGF-beta1 signaling contributes to numerous diseases, including cancer, pulmonary fibrosis, liver cirrhosis, and autoimmune disorders. Overproduction drives fibrotic remodeling through excessive extracellular matrix deposition, while loss of function can impair immune suppression and tissue homeostasis. The TGFB1 antibody is a critical tool for analyzing these disease mechanisms, allowing assessment of active and latent forms of the cytokine. It is widely used in immunohistochemical detection of TGF-beta1 expression in fibrotic lesions, tumors, and inflamed tissues.In cancer, Transforming growth factor beta-1 exhibits dual roles?acting as a tumor suppressor in early stages and a tumor promoter in advanced disease. It enhances epithelial cell migration and invasion by inducing EMT and modifying the tumor microenvironment. The TGFB1 antibody allows researchers to explore these context-dependent effects, providing insight into how TGF-beta1 transitions from growth inhibitory to pro-metastatic functions. In immunology, this cytokine maintains peripheral tolerance by inducing regulatory T cells and suppressing inflammatory responses.The TGFB1 antibody performs effectively in western blotting, ELISA, and immunohistochemistry. It provides robust detection of both precursor and mature forms of Transforming growth factor beta-1. NSJ Bioreagents supplies this antibody with validated specificity for research in fibrosis, oncology, and immunoregulation. By supporting detailed examination of TGF-beta signaling and cytokine activity, the TGFB1 antibody enables discovery in molecular pathways that link development, immune balance, and tissue remodeling.