Anti-TENM1 / Teneurin 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TENM1 antibody detects Teneurin 1, a large type II transmembrane protein involved in neuronal connectivity, axon guidance, and cell-cell adhesion. Encoded by the TENM1 gene on chromosome Xq25, Teneurin 1 belongs to the teneurin family of developmental regulators characterized by large extracellular domains containing EGF-like and YD-repeat motifs that mediate homophilic and heterophilic interactions. During embryonic development, Teneurin 1 is prominently expressed in the nervous system, particularly in sensory ganglia and the olfactory bulb, where it contributes to the establishment of topographic neuronal maps and synaptic specificity.Teneurin 1 functions through both its extracellular and intracellular domains. The intracellular region can be proteolytically cleaved and translocated to the nucleus, where it may regulate gene transcription. The extracellular domain mediates adhesion between neurons and their target cells, guiding axons toward correct synaptic partners. Loss of TENM1 disrupts neural circuit formation and has been associated with neurodevelopmental disorders, including intellectual disability and autism spectrum conditions. The TENM1 antibody is a critical tool for investigating axon guidance mechanisms, neuronal differentiation, and cell adhesion processes within the central nervous system.In addition to its developmental roles, Teneurin 1 contributes to cancer cell adhesion and metastasis. Aberrant expression has been detected in glioblastoma and neuroblastoma, linking TENM1 to oncogenic signaling pathways. The antibody detects both full-length membrane-bound and cleaved intracellular forms, supporting comprehensive study of its signaling functions. Immunohistochemical analysis reveals TENM1 localization along neuronal membranes and synaptic sites, while western blot identifies multiple high molecular weight bands reflecting post-translationally modified isoforms. The TENM1 antibody therefore serves as a versatile reagent for studies in neurobiology and tumor progression. NSJ Bioreagents provides this antibody validated for its applications, enabling detailed investigation of Teneurin 1-mediated cellular communication.