Anti-Syntaxin-1A Rabbit Monoclonal Antibody (Clone RM367)

Syntaxin-1A is a type II integral membrane protein and member of the SNARE complex that has a major role in neuronal exocytosis. It is composed of a cytoplasmic N-terminal regulatory domain, a coiled-coil SNARE domain that mediates protein-protein interactions, and a C-terminal transmembrane tail that is required for membrane localization. Syntaxin-1A is located primarily on neuronal plasma membranes and associates with synaptosomal-associated protein 25 (SNAP-25), vesicle-associated membrane protein (VAMP), and the syntaxin-binding protein Munc18 to form the SNARE complex, which facilitates synaptic vesicle docking and neurotransmitter release in a calcium-dependent manner. It is also found in pancreatic beta cells, where it is involved in insulin secretion, as well as in the heart. STX1A SNPs have been found in patients with Asperger syndrome, attention-deficit hyperactivity disorder (ADHD), or coronary artery disease. Cayman's Syntaxin-1A Rabbit Monoclonal Antibody (Clone RM367) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Hemolysin Co-regulated Protein 1, HPC-1, Stx-1A. Immunogen: Peptide corresponding to residues near the N-terminal of human syntaxin-1A. Clone Designation: RM367. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Human syntaxin-1A.