Anti-Syntaxin-1A (human), Rabbit Monoclonal (RM367)

Recombinant Antibody. This antibody reacts to human, mouse, and rat Syntaxin-1A. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxin-1A (Neuron-specific antigen HPC-1) belongs to the Q-SNARE protein family that participates in exocytosis. Syntaxin-1A is a t-SNARE abundantly expressed in most neurons and localized on the neuronal plasma membrane, where it participates in the formation of the trans-SNARE complex by engaging t-SNARE SNAP25 (synaptosomal-associated protein 25) and v-SNARE synaptobrevin (a.k.a. vesicle-associated membrane protein2 or VAMP2) to allow fusion between the synaptic vesicle and plasma membrane. Two types of syntaxin 1 isoforms exist. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.