Anti-SUPT5H / SPT5

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ7104 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Transcription elongation factor SPT5 is a... more
Product information "Anti-SUPT5H / SPT5"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene. Enables enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy, regulation of RNA metabolic process, and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex. Protein function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. [The UniProt Consortium]
Keywords: Anti-SPT5, Anti-hSPT5, Anti-SUPT5H, Anti-DSIF p160, Anti-Tat-CT1 protein, Anti-DSIF large subunit, Anti-Tat-cotransactivator 1 protein, Anti-Transcription elongation factor SPT5, Anti-DRB sensitivity-inducing factor large subunit, SUPT5H Antibody / SPT5
Supplier: NSJ Bioreagents
Supplier-Nr: RQ7104

Properties

Application: WB, IHC (paraffin), IF, FC, Direct ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant human protein (amino acids Q533-A1087)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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