Anti-SOS1 / Son of sevenless 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SOS1 antibody detects Son of sevenless homolog 1, a guanine nucleotide exchange factor (GEF) that activates Ras and Rac GTPases, serving as a critical link between receptor tyrosine kinases and downstream signaling cascades. SOS1 catalyzes the exchange of GDP for GTP on Ras, thereby triggering MAPK and PI3K pathway activation. The SOS1 antibody is widely used in cell signaling, oncology, and developmental biology to study Ras-mediated signal transduction and growth control.SOS1 is encoded by the SOS1 gene on human chromosome 2p22.1. The protein is approximately 1333 amino acids long and consists of several domains: an N-terminal histone-like fold, a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, and a C-terminal catalytic region responsible for Ras activation. SOS1 is recruited to the plasma membrane through interaction with adaptor proteins such as GRB2 following growth factor stimulation.The SOS1 antibody detects a 155 kilodalton protein in western blot assays and shows cytoplasmic and membrane localization by immunofluorescence. Upon receptor activation, SOS1 facilitates Ras activation at the plasma membrane, leading to phosphorylation of ERK and other downstream targets. Through its DH-PH domains, SOS1 also activates Rac, linking actin cytoskeleton remodeling to growth factor signaling.SOS1 plays essential roles in development, cell proliferation, and differentiation. Germline mutations in SOS1 cause Noonan syndrome, a developmental disorder characterized by short stature and congenital heart defects. In cancer, overexpression or dysregulation of SOS1 contributes to aberrant Ras activation and uncontrolled growth signaling. Its activity is finely tuned by feedback loops involving phosphorylation, ubiquitination, and membrane recruitment dynamics.Because of its central position in the Ras signaling cascade, SOS1 is a valuable target for understanding receptor-driven proliferation and oncogenic transformation. NSJ Bioreagents provides a validated SOS1 antibody optimized for its applications, supporting research into Ras activation, MAPK pathway signaling, and cell differentiation control.