35 products were found matching "K03099"!

MRTX-0902 is an inhibitor of the protein-protein interaction between son of sevenless homolog 1 (SOS1) and K-Ras containing a glycine-to-cysteine mutation at position 12 (K-RasG12C, Ki = 1.9 nM). It is selective for the SOS1-K-RasG12C protein-protein interaction over the SOS1 and wild-type K-Ras protein-protein...

Protein function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by...

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence...

Protein function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by...

Protein function: Promotes the exchange of Ras-bound GDP by GTP. [The UniProt Consortium]

Recombinant human SOS1 (son of sevenless homolog 1), encompassing amino acids 564-1049. This construct contains a C-terminus Flag-tag. This recombinant protein was affinity purified.

Protein function: Promotes the exchange of Ras-bound GDP by GTP. [The UniProt Consortium]

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by...

Protein function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by...

The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras...

Protein function: Promotes the exchange of Ras-bound GDP by GTP. [The UniProt Consortium]

Human Son of sevenless homolog 1 (SOS1), also known as guanine nucleotide exchange factor 1 (GF1), GenBank Accession No. NM_005633, a.a. 594-1049, with N-terminal FLAG-tag and C-terminal Avi-tag, expressed in a Baculovirus infected Sf9 cell expression system, MW=57 kDa. This protein is enzymatically biotinylated...