Anti-SMN1

Anti-SMN1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-863A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-863A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-863A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear... more
Product information "Anti-SMN1"
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). [The UniProt Consortium]
Keywords: Anti-SMN, Anti-SMN1, Anti-SMN2, Anti-SMNC, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein
Supplier: Bethyl Laboratories
Supplier-Nr: A301-863A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A301-863A-T maps to a region between residue 244 and 294 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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