- Search results for K13129
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50 products were found matching "K13129"!
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Item number: ELK-ELK0922.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human SMN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human SMN1. Next,...
Keywords: | SMN, SMN1, SMNC, SMN2, Gemin-1, Component of gems 1, Survival motor neuron protein |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay29028-5
Risdiplam is a survival of motor neuron-2 (SMN2) splicing modifier. It enhances SMN2 splicing (EC1.5x = 40 nM) and increases SMN protein levels (EC1.5x = 163 nM) in cellular assays. Risdiplam (3 mg/kg) increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of mild spinal muscular...
Keywords: | RG-7916, RO7034067,... |
Application: | SMN2 splicing modifier |
CAS | 1825352-65-5 |
MW: | 401.5 D |
From 50.00€
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Item number: A301-863A
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
Keywords: | Anti-SMN, Anti-SMN1, Anti-SMN2, Anti-SMNC, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay26757-1
LMI070 is an SMN2 splice modulator. It selectively enhances SMN2 splicing by stabilizing the complex formed by the U1 small nuclear ribonucleic protein (snRNP) and SMN2 pre-mRNA. LMI070 (3-30 mg/kg) increases the expression of the full-length SMN2 trancript and, at doses ranging from 0.3 to 30 mg/kg, increases SMN...
Keywords: | Branaplam, NVS-SM1, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-phenol |
Application: | SMN2 splice modulator |
CAS | 1562338-42-4 |
MW: | 393.5 D |
From 60.00€
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Item number: AG-20T-0003-C200
Monoclonal Antibody. Recognizes a sequence of up to 9 amino acids in the N-terminal domain of human SMN. Isotype: Mouse IgG1. Clone: 7B10. Applications: IP, WB. Liquid. In PBS. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the...
Keywords: | Anti-SMN, Anti-SMN1, Anti-SMNC, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
Application: | IP, WB |
Host: | Mouse |
Species reactivity: | human |
330.00€
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Item number: ARG64148.100
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
Keywords: | Anti-SMN, Anti-SMN2, Anti-SMNC, Anti-SMN1, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
Application: | ELISA, WB |
Host: | Goat |
Species reactivity: | human |
784.00€
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Item number: A301-862A
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
Keywords: | Anti-SMN, Anti-SMN1, Anti-SMN2, Anti-SMNC, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay14136-100
Tudor domains are small protein structural motifs of ~50 amino acids related to the "Royal family" of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism,...
Keywords: | SMN, SMN1, SMN2, SMNC, Gemin-1, Gemin-1, Component of gems 1, Component of gems 1, Survival motor neuron protein, Survival... |
Application: | Binding assays |
Expressed in: | E.coli |
Origin: | human |
MW: | 42,6 kD |
465.00€
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Item number: G-MOFI01117.96
Application: | ELISA |
Species reactivity: | mouse |
694.00€
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Item number: NSJ-R32249
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The Survival of Motor Neuron gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of...
Keywords: | Anti-SMN, Anti-SMNC, Anti-SMN1, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein,... |
Application: | WB, IHC (paraffin) |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
755.00€
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Item number: NSJ-R33427-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Survival of motor neuron, SMN1, SMN2 Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome....
Keywords: | Anti-SMN, Anti-SMN1, Anti-SMNC, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein, SMN... |
Application: | WB, ELISA (peptide) |
Host: | Goat |
Species reactivity: | human |
755.00€
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Item number: Cay18526-10
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been...
Keywords: | Chemical Upregulator of SMN Protein-1, (5-bromo-3-pyridinyl)(4-methylphenyl)-methanone |
Application: | SMN upregulator |
CAS | 337932-29-3 |
MW: | 276.1 D |
From 77.00€
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