Anti-SMARCA2/BRM

Anti-SMARCA2/BRM
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-015A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A301-015A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Involved in transcriptional activation and repression of select genes by... more
Product information "Anti-SMARCA2/BRM"
Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [The UniProt Consortium]
Keywords: Anti-hBRM, Anti-BAF190B, EC=3.6.4.-, Anti-SNF2-alpha, Anti-Protein brahma homolog, Anti-BRG1-associated factor 190B, Anti-ATP-dependent helicase SMARCA2, Anti-Probable global transcription activator SNF2L2
Supplier: Bethyl Laboratories
Supplier-Nr: A301-015A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse)
Immunogen: synthetic peptide. The epitope recognized by A301-015A-T maps to a region between residue 100 and 150 of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 using the numbering given in entry CAA51407.1 (GeneID 6595).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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