Anti-SLC7A11 / XCT / Solute carrier family 7 member 11

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SLC7A11 antibody detects Solute carrier family 7 member 11, a cystine/glutamate antiporter subunit that mediates cellular cystine uptake in exchange for intracellular glutamate export. SLC7A11, also known as xCT, forms part of the system Xc- transporter complex, playing an essential role in maintaining redox balance through glutathione synthesis. The SLC7A11 antibody is widely used in cancer, neurobiology, and oxidative stress research to investigate mechanisms of redox regulation and ferroptosis resistance.SLC7A11 is encoded by the SLC7A11 gene located on human chromosome 4q28.3. The protein is approximately 55 kilodaltons and partners with the heavy chain subunit SLC3A2 (4F2hc) to form a functional heterodimeric transporter. This complex mediates sodium-independent cystine uptake coupled to glutamate export. Cystine is rapidly reduced intracellularly to cysteine, a rate-limiting precursor for glutathione synthesis, which protects cells from oxidative stress. SLC7A11 activity is therefore tightly linked to redox homeostasis and cellular antioxidant capacity.The SLC7A11 antibody typically detects a 55 kilodalton protein by western blot, with strong expression in the plasma membrane and perinuclear compartments. It is transcriptionally regulated by NRF2 under oxidative stress and suppressed by p53 during stress-induced ferroptosis. Overexpression of SLC7A11 confers resistance to ferroptosis, a form of iron-dependent cell death caused by lipid peroxidation. Conversely, inhibition of SLC7A11 sensitizes cells to oxidative damage and promotes ferroptotic death, making it a key therapeutic target in oncology.Functionally, SLC7A11 expression is elevated in various cancers, including lung, breast, and pancreatic tumors, where it supports tumor growth by enhancing glutathione synthesis and metabolic reprogramming. It is also implicated in neurodegenerative diseases and ischemic injury through its role in glutamate release and excitotoxicity. NSJ Bioreagents provides a validated SLC7A11 antibody, enabling high-specificity detection of cystine transporter expression in studies of metabolism, oxidative stress, and ferroptosis signaling.