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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S5329-13B.100 | 100 µl | - | - |
3 - 19 business days* |
627.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Slc12a3, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal... more
Product information "Anti-Slc12a3 (Solute carrier family 12 Sodium/chloride transporters, member 3, Na-Cl symporter, NCC,"
Slc12a3, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Clreabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of Slc12a3 expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of Slc12a3 (2). Therefore, Slc12a3 is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that Slc12a3 has been detected in the lens cortex, core and fiber cells of rats (3). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Thiazide-sensitive sodium-chloride cotransporter |
Supplier: | United States Biological |
Supplier-Nr: | S5329-13B |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide corresponding to aa74-95 of the N-terminal tail of rat Slc12a3 (NP_062218). |
Format: | Serum |
Database Information
KEGG ID : | K14426 | Matching products |
UniProt ID : | P55018 | Matching products |
Gene ID | GeneID 54300 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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