37 products were found matching "K14426"!

Meticrane is a diuretic. It decreases the viability of Jurkat and K562 leukemia and SK-HEP-1 liver cancer cells when used at a concentration of 1 mM. Meticrane (0.125 mM) enhances cell death induced by 5-azacytidine (Cay-11164) or CUDC-101 (Cay-16426) in the same cells. Formulations containing meticrane have been...

Trichlormethiazide is a thiazide diuretic. It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine...

Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in...

Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII,...

Hydrochlorothiazide (HCTZ) is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.Formal Name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 58-93-5. Synonyms: HCTZ, NSC 53477, SU 5879....

Protein function: Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:8021284). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2, either...

A thiazide diuretic commonly used as an antihypertensive. A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and...

Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. Hydrochlorothiazide (Cay-21304) is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.Formal Name:...

Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.Formal Name:...

Methylclothiazide is a thiazide diuretic. It inhibits norepinephrine- (Cay-16673) and vasopressin-induced contractions of aortic rings isolated from spontaneously hypertensive rats at a concentration of 100 µM. Methylclothiazide reduces salt-induced increases in blood pressure in salt-sensitive but not...

The thiazide-sensitive sodium chloride cotransporter (NCC) is a member of the SLC12 family of transporters and is encoded by SLC12A3 in humans. NCC is expressed in epithelial cells of the distal convoluted tubule and localizes to the apical plasma membrane where it mediates sodium reabsorption in the kidney. It...

Indapamide-13C-d3 is intended for use as an internal standard for the quantification of indapamide by GC- or LC-MS. Indapamide is a carbonic anhydrase (CA) inhibitor (Kis = 0.23, 36, 10, and 13 nM for CAVII, CAIX, CAXII, and CAXIII, respectively). It is selective for these CAs over CAI-CAVI and CAXIV (Kis =...