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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABS-KC-6283.50 | 50 µl | - | - |
Request delivery time estimate |
232.00€
|
||
ABS-KC-6283.100 | 100 µl | - | - |
Request delivery time estimate |
332.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone... more
Product information "Anti-SIRT6"
Protein function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. [The UniProt Consortium]
Keywords: | Anti-NAD-dependent protein deacylase sirtuin-6, Anti-NAD-dependent protein deacetylase sirtuin-6, Anti-Protein mono-ADP-ribosyltransferase sirtuin-6, Anti-Regulatory protein SIR2 homolog 6, Anti-hSIRT6, Anti-SIR2-like protein 6, SIRT6 Antibody |
Supplier: | Absea |
Supplier-Nr: | KC-6283 |
Properties
Antibody Type: | Monoclonal |
Clone: | 2T17 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat, monkey |
Format: | Solution |
Database Information
KEGG ID : | K11416 | Matching products |
UniProt ID : | Q8N6T7 | Matching products |
Gene ID : | GeneID 51548 | Matching products |
Handling & Safety
Storage: | -20°C (avoid repeat freezing and thawing cycles) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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