68 products were found matching "K11416"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SIRT6 antibody detects Sirtuin 6, a nuclear NAD+-dependent deacetylase that regulates genomic stability, metabolism, and lifespan. The UniProt recommended name is NAD-dependent protein deacylase sirtuin 6 (SIRT6). This enzyme belongs to the...

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...

A SIRT6 activator, increases the deacetylation of an acetylated H3K9 peptide in a cell-free assay (EC50 = ~38 µM), selectively activates SIRT6 deacetylation activity over SIRT1, SIRT2, and SIRT3 deacetylation activities but does increase SIRT5 desuccinylation activity at 100 µM, active against M. tuberculosis (MIC =...

Active human Sirtuin 6 (GenBank Accession No. NM_016539), full length with N-terminal GST tag, MW= 65 kDa, expressed in E. coli expression system.

Protein function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a...

Recognizes human sirtuin 6. Detects a band of about 47kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-6 is a NAD-dependent protein deacetylase with activity towards 'Lys-9'and 'Lys-56'of histone H3. Modulates acetylation of histone H3 in telomeric chromatin...

MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50 = 23.3 µM) in, and reduces proliferation of,...

Recognizes human sirtuin 6. Detects a band of about 42kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-6 is a NAD-dependent protein deacetylase with activity towards 'Lys-9'and 'Lys-56'of histone H3. Modulates acetylation of histone H3 in telomeric chromatin...

Protein function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a...

Protein function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a...

The Sirtuin 6 Fluorogenic Assay Kit is a complete assay system designed to measure SIRT6 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent SIRT6 activity measurements. In addition, the kit includes purified SIRT6 enzyme and...