Anti-RNF31

Anti-RNF31
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-560A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-560A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-560A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates... more
Product information "Anti-RNF31"
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998). [The UniProt Consortium]
Keywords: Anti-HOIP, EC=2.3.2.27, Anti-RING finger protein 31, Anti-HOIL-1-interacting protein, Anti-E3 ubiquitin-protein ligase RNF31, Anti-RING-type E3 ubiquitin transferase RNF31, Anti-Zinc in-between-RING-finger ubiquitin-associated domain protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-560A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rabbit, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-560A-T maps to a region between residue 1022 and 1072 of human Ring Finger Protein 31 using the numbering given in entry NP_060469.4 (GeneID 55072).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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