Anti-RNA Polymerase II

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-835A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-835A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-835A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using... more
Product information "Anti-RNA Polymerase II"
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA- dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome. [The UniProt Consortium]
Keywords: Anti-POLR2, Anti-POLR2A, EC=2.7.7.6, EC=2.7.7.48, Anti-RNA polymerase II subunit B1, Anti-DNA-directed RNA polymerase II subunit A, Anti-DNA-directed RNA polymerase II subunit RPB1, Anti-RNA-directed RNA polymerase II subunit RPB1
Supplier: Bethyl Laboratories
Supplier-Nr: A303-835A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human, Mouse (Expected: Rat, Zebrafish, X. Tropicalis, Bovine, Dog, Rabbit, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Eukaryota, Rhodophyta, Brassicaceae, Mouse-ear Cress, Soybean, Barrel Medic, Castor Bean, Potato, Slime Mold_1054147)
Immunogen: synthetic peptide. The epitope recognized by A303-835A-T maps to a region within the C-terminal repeat of human RNA Polymerase II using the reference sequence NP_000928.1 (GeneID 5430).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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