Anti-RIPK3

Anti-RIPK3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F50171-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F50171-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. The product of this gene is a member of the... more
Product information "Anti-RIPK3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. Protein function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. [The UniProt Consortium]
Keywords: Anti-RIP3, Anti-RIPK3, Anti-RIP-3, EC=2.7.11.1, Anti-RIP-like protein kinase 3, Anti-Receptor-interacting protein 3, Anti-Receptor-interacting serine/threonine-protein kinase 3, RIPK3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F50171

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this RIPK3 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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