46 products were found matching "K08847"!

GSK843 is an inhibitor of receptor-interacting serine/threonine kinase 3 (RIPK3, IC50 = 6.5 nM). It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK843 (10 µM) induces apoptosis in L-929 fibroblasts. It inhibits TNF-alpha-induced necroptosis in primary human neutrophils in a...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse RIPK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse RIPK3. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RIPK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RIPK3. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat RIPK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat RIPK3. Next,...

GSK840 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 0.3 nM). It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK840 (0.04-1 µM) inhibits TNF-alpha-induced necroptosis in primary human neutrophils isolated from human whole blood. It also inhibits LPS-induced...

GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3). It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 µM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced...

Anti-RIP3 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with RIP3 with Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with RIP3 from other sources has not been determined. RIP3...

HS-1371 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 20.8 nM). It inhibits basal RIPK3 autophosphorylation and TNF-alpha- or TRAIL-induced necroptosis in HT-29 cells when used at a concentration of 5 µM. It also inhibits necroptosis induced by a TNF-alpha Smac mimetic and the caspase...

Protein function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic...

Protein function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic...

Anti-Receptor-interacting serine-threonine kinase 3 Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from human and chimpanzee based on 100% homology with the immunizing sequence. Cross-reactivity with...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Receptor-interacting serine/threonine-protein kinase 3(RIPK3), also known as RIP3, is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein (RIP) family of...